Intravesical instillation of MMC adding IFN-α2b for preventing postoperative recurrence of bladder cancer

Objective To investigate the effective method for preventing the postoperative recurrence of bladder cancer. Methods 62 cases of bladder cancer were treated by conservative bladder operations including TURBt and partial cystectomy,and followed by postoperative intravesical instillation of MMC adding IFN-α2b. 68 cases of bladder cancer as control group were treated by identical operations and instilled with MMC after operation only.The preventive effect of two groups was compared. Results The recurrence rate of MMC+IFN group was 8.5%,which was less than MMC group,and the side-effects occurred in MMC+IFN group were very mild. Conclusions Intravesical instillation of MMC adding IFN-α2b is an effecfive method for preventing recurrence of bladder cancer.