With the extensive application of Chinese materia medica,Adverse reaction of Chinese materia medica and the safety of it has catch more attention than before.The most important problem we should solve is to raise the safety of Chinese materia medica.Compared with ADR of westen materia medica,ADR of Chinese materia medica has some Particularity.Both the cause of ADR of Chinese materia medica and evaluation of it is very complicated.To raise the safety of Chinese materia medica,we should perfect laws and regulations,make better report of ADRS and carry out toxicology more profoundly.Moreover,we can integrate computery,data-mining technique and epidemiology based on consummate database to explore new method of ADR evaluation.