Objective To discuss the effect of amiodarone on treating ventricular arrhythmia by dynamic ECG. Methods A total of 150 cases of patients with ventricular arrhythmia were treated by oral administration of amiodarone. In the first three days, took amiodarone 200 mg orally every time,three times a day; in the second three days, took amiodarone 200 mg orally every time ,twice a day; in the last three days, took amiodarone 200 mg orally every time ,once a day. The dynamic ECG examination before and after the treatment were taken at the 3rd day, the 6th day and the 9th day. The data of ventricular arrhythmia was analyzed before and after treatment. Results The dynamic ECG examination shows that taking amiodarone has a good effect on the ventricular arrhythmia, 132 cases have a good effect among the 150 cases (the effective rate is 88%). Conclusion Dynamic ECG is a necessary examination to check the effect of amiodarone on ventricular arrhythmia.