System Evaluation of Brain-Targeted Nasal Delivery Preparation

Objective: To evaluate intranasal administration as one of the ways of brain-targeted drug delivery system.Method: Showing the advantages of nasal administration through building the in vitro model of blood-brain barrier and researching the evaluation methods of drug concentration in brain.Result:The intranasal administration can increase the concentration of drug in the brain so as to accomplish braintargeted drug delivery.Conclusion:Lack of in-depth understanding of blood-brain barrier is still the major problem existing in the brain-targeted drug delivery system,but with further studies on the transport mechanism of blood-brain barrier,the structural connection between nasal cavity and brain,the pathogenesis in the brain and the pharmacokinetics of brain-targeting drug a breakthrough in the research on brain-targeted drug delivery system can be expected.