Relationship between Type C natriuretic peptide and hypertension and left ventricle hypertrophy

AIM:To investigate the correlations between plasma Type C natriuretic peptide(CNP) levels and the degree of hypertension and left ventricle hypertrophy in stroke-prone spontaneously hypertensive rats (SHR_ SP ). METHODS:The plasma concentrations of CNP were measured by means of radioimmunoassay in SHR_ SP and compared with those of normotensive rats (Wistar-Kyoto rat,WKY). RESUTLS:Systolic blood pressure (SBP) and left ventricle puls septum (LV+S) weight and (LV+S)/body weight (BW) ratio were markedly higher in SHR_ SP than in WKY (P0.01). Plasma CNP levels were 145±42 ng/L and 72±11 ng/L in SHR_ SP and in WKY respectively,and the difference were significant (P0.01). There were positive correlations between CNP and SBP as well as CNP and (LV+S)/BW (P0.05),while CNP had no significant correlations with heart rate (HR),right ventricle (RV) weight and BW(P0.05). CONCLUSION:CNP may reflex the degree of hypertension and left ventricle hypertrophy.