纳米载体
纳米技术
药物输送
体内分布
毒品携带者
药品
内化
靶向给药
化学
生化工程
计算机科学
生物物理学
材料科学
生物
药理学
生物技术
体内
工程类
细胞
生物化学
作者
C. Geraldine M. Jordan,Vladimir V. Shuvaev,Mark M. Bailey,Vladimir R. Muzykantov,Thomas D. Dziubla
标识
DOI:10.2174/1381612822666151216151856
摘要
For a variety of diseases, effective therapy is severely limited or rendered impossible due to an inability to deliver medications to the intended sites of action. Multiple barriers exist through the body, which have evolved over time to limit the migration of foreign compounds from entering the tissues. Turning toward biology as inspiration, it has been the general goal of drug delivery to create carrier strategies that mimic, in part, features of bacteria/ viruses that allow them overcome these barriers. By packaging drugs into nano and micron scale vehicles, it should be possible to completely change the biodistribution and residence times of pharmaceutically active compounds. Recently, due to advances in formulation technologies, it has become possible to control not just the material selection, surface chemistry, and/or size, but also the overall geometry and plasticity of the drug carriers. These approaches aid in the formulation of nonspherical particles such as, discs, rods, and even unique structures such as cubes and nanodiamonds. The adjustment of size and shape can be used for the aid or prevention in cellular uptake and also to overcome the vascular and mucosal barrier. In this review, we present a summary of some approaches used to control carrier shape and the impact these geometries have upon drug transport across biological barriers. Keywords: Nanocarriers, internalization, drug targeting, nanoparticles.
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