Objective To analyze the procalcitonin(PCT) and C reactive protein(CRP)in the combined detection of diseases in clinical infection,proves that the combined detection of PCT and CRP has important clinical value in diagnosis of infectious diseases.Methods 40 cases of the virus in our hospital from 2012 January to 2013 January were infectious disease,80 cases of bacterial infection disease patients and 40 healthy subjects were used in immunofluorescence analysis and immunenephelometry procalcitonin and C reactive protein,and then the test results were analyzed.Results Severe bacterial infection group(Zu),the general bacterial infection group(Group II) procalcitonin levels were significantly higher than that ofviral infection group(Group III) and control group(Zu),the difference was statistically significant(P0.05);the positive correlation between bacterial infection group PCTand CRP,and group PCT with no relationship between CRP virus infection.Conclusion The procalcitonin and C reactive protein can be used for clinical diagnosis of infectious diseases,and procalcitonin compared with C reactive protein more in bacterial infection in clinical infection,combined detection of PCT and CRP diseasebetter effect,has great diagnostic value.