Based on the former testing and research achievements of rock mechanics in Dongguashan deep brittle rock mining, the elastic-plastic constitutive model is constructed. With mathematical statistics method to design computer model and analyze the results of numerical simulation, the sensitivity of rock mass mechanics parameters(elastic modulus E, Poisson ratio μ, cohesive force C, density ρ and friction angle φ) influencing stope stability is studied. From the analysis of wall-rock displacement, the influencing degrees of these rock parameters on the stability of rock mass of stope are obtained. The results indicate that the change of E has the greatest influence on stope stability, the next is μ, meanwhile, both the change of φ and ρ is insensitive to the stope stability. Moreover, the bigger the modulus E is, the smaller the rock mass displacement is. The influence of μ and C on rock mass displacement is the same as E does.