Adiponectin is one of the adipocytokines that is derived from adipose tissue.It has anti-inflammatory,anti-diabetic,anti—atherogenic and insulin-sensitizing effects.Recent researches show Adiponectin is relational with chronic liver disease,In text,we describe adiponectin,source,adiponectin,structure,adiponectin,biological function and effect of adiponectin in chronic liver disease.