To explore the mechanism of the occurrence of damp-warm disorders,the clinical symptoms and the contents of blood endogenous toxin,TNF-α and IL-1 were detected. Results: In the damp-heat environment,the temperature rose,and the contents of endogenous toxin,TNF-α and IL-1 increased; the clinical symptoms comprised fatigue,poor appetite and sticky stools. It is concluded that damp-heat environment may result in damp-warm disorders.