伤口愈合
慢性伤口
伤口护理
注意事项
医学
生物医学工程
金黄色葡萄球菌
炎症
渗出液
多路复用
计算机科学
病理
重症监护医学
外科
免疫学
生物
细菌
电信
遗传学
作者
Yu-Ji Gao,Dat T. Nguyen,Trifanny Yeo,Su Bin Lim,Wei Xian Tan,Leigh Madden,Lin Jin,Ji Yong Kenan Long,Fazila Aloweni,Yi Jia Angela Liew,Mandy Li Ling Tan,Shin Yuh Ang,D Sivagame,O Maniya,Ibrahim Abdelwahab,Kian Ping Loh,Chia-Hung Chen,David L. Becker,David I. Leavesley,John S. Ho,Chwee Teck Lim
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2021-05-21
卷期号:7 (21)
被引量:106
标识
DOI:10.1126/sciadv.abg9614
摘要
Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor-α, interleukin-6 (IL-6), IL-8, and transforming growth factor-β1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.
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