槲皮素
抗氧化剂
消炎药
壳聚糖
生物利用度
Zeta电位
化学
多酚
多糖
水溶液
溶解度
傅里叶变换红外光谱
炎症
差示扫描量热法
纳米颗粒
抗氧化剂
核化学
生物化学
药理学
医学
免疫学
作者
Hee−Jong Moon,Pattawika Lertpatipanpong,Yukyung Hong,Chong-Tai Kim,Seung Joon Baek
标识
DOI:10.1016/j.jff.2021.104756
摘要
Dietary polyphenols including quercetin are secondary plant metabolites that have been reported to prevent many chronic diseases; however, the high hydrophobicity of quercetin results in low water solubility and bioavailability, which limits the therapeutic efficacy and impedes further applications in aqueous systems. Encapsulation may be a potential solution to the aforementioned problems. Some polysaccharides, including soluble soybean polysaccharides (SSPS) and chitosan, were widely used as polymeric backbones for the formation of nanoparticles. We investigated the physicochemical property of encapsulated quercetin in SSPS with chitosan. Encapsulation of quercetin was confirmed using Dynamic light scattering, Zeta potential, Fourier-transform infrared spectroscopy, Differential scanning calorimetry, and Transmission electron microscopy. The biological activity of this nanoparticle showed that encapsulated quercetin exhibits better biological activity compared to free quercetin. Alongside the enhanced solubility of quercetin in an aqueous solution, our results illustrate the improved utility of this nanoparticle in the biomedical and food industry.
科研通智能强力驱动
Strongly Powered by AbleSci AI