化学
脂质体
杰纳斯
膜
金属
纳米技术
材料科学
生物化学
冶金
作者
Huihui Hu,Jieyu Zhu,Lingyun Cao,Zhiye Wang,Yuan Gao,Liulin Yang,Wenbin Lin,Cheng Wang
出处
期刊:Chem
[Elsevier]
日期:2022-02-01
卷期号:8 (2): 450-464
被引量:8
标识
DOI:10.1016/j.chempr.2021.10.020
摘要
Summary
Photo-generation of a proton gradient over a lipid bilayer is of interest due to its essential role in photosynthetic bacteria. Membrane asymmetry is key to the proton gradient generation via directional proton transport. Here, we report a light-driven proton pump based on two-dimensional, porphyrin-based Janus metal-organic layers (Janus-MOLs). The Janus-MOL, functionalized with carboxyquinone on one side and Acitretin on the other via a microemulsion-based method, was attached to liposome surface. Upon photoexcitation, the porphyrins initiate electron and hole transfers to carboxyquinone and Acitretin, respectively, which undergo redox reactions with freely diffusing quinone (Q)/hydrosemiquinone (HQ·) in the lipid bilayer to produce a concentration gradient of quinone-based species. Owing to different pKa values of HQ+ and HQ·, these redox reactions trigger proton transport across the membrane to create a pH gradient, which drives ATP production by CFoF1-ATP synthase in a similar fashion as photosynthetic bacteria.
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