骨癌
医学
机制(生物学)
生活质量(医疗保健)
癌症疼痛
神经病理性疼痛
重症监护医学
骨痛
癌症
神经科学
心理学
药理学
内科学
哲学
护理部
认识论
作者
Xuan-Qi Zheng,Yu-Hao Wu,Jinfeng Huang,Ai-Min Wu
标识
DOI:10.1016/j.jare.2021.06.006
摘要
Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected.Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies.Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.
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