RNA methylation preserves ES cell identity by chromatin silencing of retrotransposons

Liu, J. et al. The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature 591 , 322–326 (2021). Article CAS Google Scholar Lu, F. & Zhang, Y. Cell totipotency: molecular features, induction, and maintenance. Natl Sci. Rev. 2 , 217–225 (2015). Article CAS Google Scholar Jiang, X. et al. The role of m6A modification in the biological functions and diseases. Sig. Transduct. Target. Ther. 6 , 74 (2021). Article CAS Google Scholar Wang, J. et al. Leukemogenic chromatin alterations promote AML leukemia stem cells via a KDM4C-ALKBH5-AXL signaling axis. Cell Stem Cell 27 , 81–97.e88 (2020). Article CAS Google Scholar Chen, C. et al. Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos. Protein Cell 12 , 455–474 (2021). Article CAS Google Scholar Download references