医学
心脏病
疾病
自闭症
载脂蛋白E
神经影像学
认知
神经科学
精神科
生物信息学
病理
心理学
生物
作者
Sarah N. Nattel,Laura Adrianzen,Erica C. Kessler,Grégor Andelfinger,Mathieu Dehaes,Gabriel Côté-Corriveau,M. Pilar Trelles
标识
DOI:10.1016/j.cjca.2017.09.020
摘要
Children with congenital heart disease (CHD) are at increased risk of neurodevelopmental disorders (NDDs) and psychiatric conditions. These include cognitive, adaptive, motor, speech, behavioural, and executive functioning deficits, as well as autism spectrum disorder and psychiatric conditions. Structural and functional neuroimaging have demonstrated brain abnormalities in young children with CHD before undergoing surgical repair, likely as a result of an in utero developmental insult. Surgical factors do not seem to play a significant role in neurodevelopmental outcomes. Specific genetic abnormalities, particularly copy number variants, have been increasingly implicated in both CHD and NDDs. Variations in genes involved in apolipoprotein E (APOE) production, the Wnt signalling pathway, and histone modification, as well as in the 1q21.1, 16p13.1-11, and 8p23.1 genetic loci, have been associated with CHD and NDDs and are important targets for future research. Understanding these associations is important for risk stratification, disease classification, improved screening, and pharmacologic management of individuals with CHD.
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