C−H Carboxylation of Aromatic Compounds through CO2 Fixation

Abstract Carbon dioxide (CO2) represents the most abundant and accessible carbon source on Earth. Thus the ability to transform CO2 into valuable commodity chemicals through the construction of C−C bonds is an invaluable strategy. Carboxylic acids and derivatives, the main products obtained by carboxylation of carbon nucleophiles by reaction of CO2, have wide application in pharmaceuticals and advanced materials. Among the variety of carboxylation methods currently available, the direct carboxylation of C−H bonds with CO2 has attracted much attention owing to advantages from a step‐ and atom‐economical point of view. In particular, the prevalence of (hetero)aromatic carboxylic acids and derivatives among biologically active compounds has led to significant interest in the development of methods for their direct carboxylation from CO2. Herein, the latest achievements in the area of direct C−H carboxylation of (hetero)aromatic compounds with CO2 will be discussed.