生物
干细胞
细胞生物学
再生(生物学)
人口
再生医学
骨骼肌
干细胞衰老理论
神经科学
解剖
祖细胞
医学
干细胞因子
环境卫生
作者
Ara B. Hwang,Andrew S. Brack
出处
期刊:Current Topics in Developmental Biology
日期:2018-01-01
卷期号:: 299-322
被引量:50
标识
DOI:10.1016/bs.ctdb.2017.08.008
摘要
Satellite cells (SCs) are a population of muscle-resident stem cells that are essential for efficient tissue repair. SCs reside in a relatively quiescent state during normal tissue turnover, but are activated in response to injury through the microenvironment and cell-intrinsic signals. During aging, SC dysfunction is a major contributor to the decline in regenerative potential of muscle tissue. Recent studies have demonstrated that both cell-intrinsic and cell-extrinsic factors are deregulated during aging. Interventions that reverse age-associated changes in SCs or the niche have shown to partially rejuvenate the regenerative capacity of aged muscle SCs. In this review, we discuss recent advances in SC biology as it pertains to the deleterious effects of aging. A better understanding of how age-dependent changes in the SC and its environment niche impact muscle regeneration could lead to interventions to ameliorate the effects of aging in humans.
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