Biological extraction of realgar byAcidithiobacillus ferrooxidansand itsin vitroandin vivoantitumor activities

雄黄 体内 药理学 化学 三氧化二砷 体外 细胞毒性 生物浸出 毒性 细胞凋亡 生长抑制 生物 生物化学 矿物学 生物技术 有机化学
作者
Xu Zhang,Qinjian Xie,Xin Wang,Bo Wang,Hongyu Li
出处
期刊:Pharmaceutical Biology [Taylor & Francis]
卷期号:48 (1): 40-47 被引量:17
标识
DOI:10.3109/13880200903029381
摘要

Acidithiobacillus ferrooxidans is a Gram-negative, chemolithoautotrophic bacterium involved in metal bioleaching. It is used for the extraction of coarse medical realgar, which is converted into an aqueous solution. To prove its feasibility as an anticancer drug candidate, extracted realgar (ER/Af) was evaluated for its antitumor activities both in vitro and in vivo. In cytotoxicity tests, ER/Af displayed significant inhibition on cell proliferation of HepG2, SMMC7721, and H22 cells in a time and dose dependent manner. Remarkable tumor growth inhibition and survival time prolongation effects, along with no obvious toxicity, were observed in antitumor experiments against H22 cell-bearing mice. Apoptosis induction was also confirmed as one of the mechanisms involved in the efficacy of ER/Af both in vitro and in vivo. The most important observation is that ER/Af showed high selective affinity to tumor tissues with about eight-fold higher arsenic accumulations at the tumor site of mice than those of the arsenic trioxide (ATO)-treated group at the same dose (57.8 ± 3.34 μg/g dry tissue vs. 7.6 ± 0.88 μg/g dry tissue). In conclusion, A. ferrooxidans could be successfully used for the extraction of realgar and ER/Af was proved to be a promising anticancer drug candidate, which is valuable for further study and clinical trials.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李紫悠发布了新的文献求助10
刚刚
渠建武完成签到 ,获得积分10
1秒前
2秒前
ccm应助宁燕采纳,获得10
3秒前
SAMCHU应助高赛文采纳,获得10
5秒前
phantom完成签到 ,获得积分10
6秒前
医学骷髅完成签到,获得积分10
8秒前
9秒前
SciGPT应助HK采纳,获得10
9秒前
yyyrrr完成签到,获得积分10
11秒前
11秒前
12秒前
12秒前
汉堡包应助ppat5012采纳,获得10
14秒前
14秒前
复杂的雪巧完成签到,获得积分10
15秒前
fffbl发布了新的文献求助10
15秒前
Ava应助Dawn采纳,获得10
15秒前
dd发布了新的文献求助10
16秒前
vobei完成签到 ,获得积分10
16秒前
16秒前
Sugaryeah发布了新的文献求助10
18秒前
专注水壶发布了新的文献求助10
18秒前
热心的访波完成签到 ,获得积分10
19秒前
钦泽发布了新的文献求助10
19秒前
21秒前
呆萌冷雪完成签到,获得积分10
21秒前
21秒前
Pendulium发布了新的文献求助10
21秒前
21秒前
脑洞疼应助fffbl采纳,获得10
22秒前
Alice完成签到,获得积分10
23秒前
医学骷髅发布了新的文献求助10
23秒前
orixero应助叶子采纳,获得10
23秒前
小蘑菇应助威武的皮皮虾采纳,获得30
24秒前
24秒前
爆米花应助lqkcqmu采纳,获得10
26秒前
27秒前
wanci应助西奥采纳,获得10
28秒前
11111111发布了新的文献求助10
28秒前
高分求助中
Adhesion Science: Principles & Practice 1234
Signals, Systems, and Signal Processing 610
Burger's Medicinal Chemistry and Drug Discovery 400
A Step-by-Step Guide to Qualitative Data Coding 2nd Edition 400
Impact of Storage Orientation and Duration on Prefilled Syringe Performance: Break-Loose and Glide Forces, and Injection Time Across Multiple Time Points 360
Programming for Chemical Engineers Using C, C++, and MATLAB 300
Upland Kenya wild flowers and ferns: a flora of the flowers, ferns, grasses, and sedges of highland Kenya 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6668476
求助须知:如何正确求助?哪些是违规求助? 8417468
关于积分的说明 17993978
捐赠科研通 5876812
什么是DOI,文献DOI怎么找? 2976863
邀请新用户注册赠送积分活动 1952752
关于科研通互助平台的介绍 1880892