第二组内含子
核酶
内含子
第一组催化内含子
RNA剪接
后转座子
基因组
生物
小剪接体
遗传学
核糖核酸
机制(生物学)
折叠(DSP实现)
计算生物学
基因
进化生物学
物理
转座因子
电气工程
工程类
量子力学
作者
Olga Fedorova,Nora Zingler
摘要
Abstract Group II introns are large autocatalytic RNAs found in organellar genomes of plants and lower eukaryotes, as well as in some bacterial genomes. Interestingly, these ribozymes share characteristic traits with both spliceosomal introns and non-LTR retrotransposons and may have a common evolutionary ancestor. Furthermore, group II intron features such as structure, folding and catalytic mechanism differ considerably from those of other large ribozymes, making group II introns an attractive model system to gain novel insights into RNA biology and biochemistry. This review explores recent advances in the structural and mechanistic characterization of group II intron architecture and self-splicing.
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