B-Cell Lymphoma With Intermediate- to High-Grade Features and Different Immunophenotypic Profiles Involving Separate Anatomic Sites With a Good Response to R-CHOP

The occurrence of B-cell lymphoma with intermediate- to high-grade features and different immunophenotypic profiles involving separate anatomic sites is uncommon. We describe such a case and present results of ancillary studies that characterized this B-cell lymphoma. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) and intrathecal methotrexate with a good clinical response.