Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize UG Wobble

The genetic code is deciphered by the anticodons of tRNAs,whichcarryanaminoacidatthe3 end,bindtoaspecificcodonin the mRNA, and transfer their amino acid to the growingpolypeptide chain on the ribosome. In codon-anticodon inter-actions in the ribosome, the second and third bases (positions35 and 36) of the anticodon base pair with the second and firstbases of the codon, respectively, following Watson-Crick(WC)