Objective To evaluate the curative effect and tolerability of intravenous nitrates combined with diltiazem on angina pectoris.Methods 100 patients with coronary heart disease were chose.Diltiazem was added to the routine therapy of nitrates and anticoagulants.The episodes,duration of angina attack,changes of electrocardiogram were observed before and after treatment in a month.Results The effective rate of intravenous nitrates in treating angina pectoris was 85%,and the effective rate of intravenous nitrates combined with diltiazem was 90%.Conclusion Diltiazem has certain effect in treating angina pectoris,it can achieve even better effect when combined with nitrates.