Effect of polysaccharide from Cynanchum auriculatum Royle ex Wight against CCl_4-induced liver injury in mice

Objective:To study the protective effect of polysaccharide from Cynanchum auriculatum Royle ex Wight against CCl4-induced liver injury in mice.Methods:Eighty male mice from Kunming were rando mly divided into normal control group,model control group,positive control group,high-dosage group,middle-dosage group and low-dosage group.The mice divided into the above 6 groups were fed for 7 days.The drug groups were by gavage with 500,250,100mg/kg polysaccharide from Cynanchum auriculatum Royle ex Wight,positive control group was by gavage with 80 mg/kg solution of liver-aid tablet,normal control group and model control group were given the same volume physiological saline,On the 7th day of feeding,the mice except normal control group were given 10 mL/kg solution of CCl4,Twenty four hours after the intoxication,the serum ALT and AST content were measured in each group above.Results:Polysaccharide from Cynanchum auriculatum Royle ex Wight can significantly decreased the content of ALT and AST in serum.Conclusion:It is revealed that polysaccharide from Cynanchum auriculatum Royle ex Wight have some protective effect to CCl4-induced liver injury in mice.