Expression of the p53,bcl-2 and PCNA in retinoblastoma

Objective:To investigate the expression of p53、bcl-2 and proliferating cell nuclear antigen(PCNA).Methods:Immunohistochemical staining was used to determine the expression of the P16,P53 and PCNA in 46 cases of retinoblastoma.Results:p53、bcl-2 and PCNA were remarkably expressed in retinoblastoma retina,compared to the expressions in normal retina.Conclusions:The occurrence of Rb is the result of multiple gene mutations.The determinations of p53、bcl-2 and PCNA are significant to know the occurance、developing and diagnose of Rb.