Synthesis of ursolic acid ester and their antihepatodamage activity

This paper reports preparation of four ursolic acid derivatives. Study on protective activity of ursolic acid on CCl4 hepatic damage indicated that the ursolic acid and derivatives at the doses of 60mg/kg significantly decreased the serum AST and ALT. The ursolic acid ethylic ester showed similar activity as that of ursolic acid against hepatic damage. Compared to ursolic acid, the ursolic acid diclofop ester demonstrated more potent protection on hepatic damage, even better than DGL.