细胞毒性T细胞
异源的
细胞毒性
体外
生物
病毒学
免疫学
抗原
分子生物学
生物化学
基因
作者
Manuel Campos,Rossi Cr
出处
期刊:PubMed
日期:1986-11-01
卷期号:47 (11): 2411-4
被引量:5
摘要
Cytotoxic lymphocytes against infectious bovine rhinotracheitis virus (IBRV)-infected cells were induced by in vitro stimulation with IBRV antigen of peripheral blood leukocytes obtained from hyperimmune cattle. After one in vitro stimulation with IBRV, cytotoxicity was detected against IBRV-infected autologous target cells, but not against heterologous IBRV-infected or K562 target cells. After 4 in vitro IBRV stimulations at weekly intervals (in the presence of autologous feeder cells followed by interleukin 2 treatment at 2-day intervals), cytotoxicity was detected against autologous-, and to a lesser extent, heterologous-infected cells. Most cells in cytotoxic cultures were positive to a monoclonal antibody shown to react with bovine T lymphocytes.
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