脑刺激
磁刺激
电磁线圈
不连续性分类
计算机科学
材料科学
刺激
磁场
核磁共振
生物医学工程
医学
磁共振成像
物理
神经科学
电气工程
工程类
数学
心理学
数学分析
作者
Sonia C. P. Sousa,Jorge Almeida,Pedro C. Miranda,Ricardo Salvador,Joao Silvestre,Hugo Simoes,Paulo Crespo
出处
期刊:International Conference of the IEEE Engineering in Medicine and Biology Society
日期:2014-11-06
被引量:2
标识
DOI:10.1109/embc.2014.6943647
摘要
Transcranial magnetic stimulation (TMS) was proposed in 1985. Nevertheless, its wider use in the treatment of several neurologic diseases has been hindered by its inability to stimulate deep-brain regions. This is mainly due to the physical limiting effect arising from the presence of surface discontinuities, particularly between the scalp and air. Here, we present the optimization of a system of large multiple coils for whole-brain and half-hemisphere deep TMS, termed orthogonal configuration. COMSOL(®)-based simulations show that the system is capable of reaching the very center of a spherical brain phantom with 58% induction relative to surface maximum. Such penetration capability surpasses to the best of our knowledge that of existing state of the art TMS systems. This induction capability strongly relies on the immersion of the stimulating coils and part of the head of the patient in a conducting liquid (e.g. simple saline solution). We show the impact of the presence of this surrounding conducting liquid by comparing the performance of our system with and without such liquid. In addition, we also compare the performance of the proposed coil with that of a circular coil, a figure-eight coil, and the H-coil. Finally, in addition to its whole-brain stimulation capability (e.g. potentially useful for prophylaxis of epileptic patients) the system is also able to stimulate mainly one brain hemisphere, which may be useful in stroke rehabilitation, among other applications.
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