Objective To explore the effects of exercise on fatigue of patients with acute leukemia(AL).Methods 120 patients with AL were randomized into experimental group and control group.The experimental group was given exercise intervention and control group given no instructions regarding to exercise intervention.Results The level of fatigue and bone marrow suppression of experimental group were lower than that in the control group.There were statistical differences between the two groups(P0.05).Conclusion Exercise treatment can decrease AL patients′ fatigue level after chemotherapy.