Application of 4D-THRIVE Dynamic Contrast-Enhanced Scan in Evaluating Microvascular Permeability of Early Cervical Cancer

Objective To investigate the microvascular permeability characteristics of early cervical cancer by using4D-THRIVE dynamic contrast-enhanced magnetic resonance imaging scan,and to discuss its clinical significance. Methods A total of 30 patients with normal cervix( normal cervix group) and 48 patients with cervical cancer( cervical cancer group) were included in this study. Of the 48 patients with cervical cancer,stage I was seen in 16( all were stage Ib cervical squamous cell carcinoma),and stage II was seen in 32,including cervical squamous cell carcinoma( n = 27) and cervical adenocarcinoma( n = 5). 4D-THRIVE dynamic contrast-enhanced MRI scan was performed in all patients. On the Matlab platform,STC and CTC in the region of interest( ROI) were analyzed by non-linear fitting to obtain the permeability parameter-related Ktrans,Kepand Vevalues,and the microvascular permeability characteristics of the normal cervix group and the cervical cancer group were evaluated. Results Statistically significant differences in Ktransand Kepvalues existed between the normal cervix group and the cervical cancer group( P 0. 05),while Vevalue had no statistical significance.Statistically significant differences in Ktransand Kepvalues also existed between stage I and stage II cervical cancer( P 0. 05),while Vevalue had no statistical significance( P 0. 05). When the Ktransand Kepvalues were compared between the cervical squamous cell carcinomas and the cervical adenocarcinomas of the same grade,the differences were statistically significant( P 0. 05),while Vevalue had no statistical significance. Conclusion As a noninvasive technique,4DTHRIVE dynamic contrast-enhanced MRI scan can quantitatively analyze the microvascular permeability of cervical cancer,which is very helpful in making preoperative evaluation of the tumor's biological behavior,the cancer angiogenesis,the response to the treatment,and the sensitivity to radiotherapy and chemotherapy,and in predicting the prognosis as well.