Effect of postburn persistent hypermetabolism on e-mergence and evolution of multiple organ failure ingoats

In order to evaluate the effect of the postburn per-sistent hypermetabolism on the emergence and evolutionof multiple organ failure(MOF),animal experimentalmodel of hypermetabolism and MOF was established.16goats were burned(3rd degree,20%-25%of the totalbody surface area) by using hot water. Parameters re-flecting oxygen dynamics and organ function were stud-ied before and after burns. 11 out of the 16 goats devel-oped hypermetabolism associated with hyperdynamic cir-culation. MOF occurred in 10 of the 11 goats with an in-cidence rate of 90.9%。 Among the five non-hyperme-tabolic animals, only one goat developed MOF with anincidence of 20.0%. Hypermetabolism mostly occurredon the lst day after burn and became obvious on the 2ndday.MOF developed 2-5 days after burn in most ani-mals. It is suggested that persistent hypermetabolic statemay play an important role in the emergence and evolu-tion of MOF.