Radical Decarboxylative Functionalizations Enabled by Dual Photoredox Catalysis

Organic carboxylates are readily available feedstock chemicals, and the carboxylate group is a latent activating group which can be easily removed by decarboxylation. The radical decarboxylative functionalization by photoredox catalysis undergoes rapid development recently, with which many difficult transformations can be achieved by dual photoredox catalysis. We summarize radical decarboxylative functionalizations via additional transition metal catalysts, thiol catalysts, or hypervalent iodine catalysts, which either activate the carboxylates or enable new radical transformations.