Total enteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis

【Objectives】 This study was designed to evaluate the effects of total enteral nutrition and total parenteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis.【Methods】 107 patients were enrolled in ICU between November 2003 and December 2007.In the first week of hospitalization,54 patients received total parenteral nutrition,and 53 received total enteral nutrition.All patients were concomitantly administered with sufficient prophylactic antibiotics.CT scan and C-reaction proteins indicated a similar clinical severity in both groups.【Results】 80% subjects developed organ failure in the group with total parenteral nutrition,which was significantly higher than that in the group with total enteral nutrition(21.00%);80.00% patients in total parenteral nutrition and 22.00%(P 0.05) in total enteral nutrition underwent the surgical intervention.The incidence of pancreatic septic necroses in the group with total enteral nutrition(23.00%) was significantly lower than that in the group with total parenteral nutrition(72.00%)(P 0.05).The mortality of patients(43.00%) on total parenteral nutrition was significantly increased as compared to 11.00%(P 0.05) in the group received total enteral nutrition.【Conclusion】 Total enteral nutrition is better than total parenteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis.