Aerosol Vaccination Against Feline Panleukopenia

Forty-seven cats were vaccinated with modified live-virus feline panleukopenia (FPL) vaccine administered by a nebulizer connected to a metal vaccination chamber. All 29 cats that dif not have FPL serum-neutralizing (SN) antibodies at the time of vaccination developed high SN titers. Five were then exposed to virulent FPL virus. Clinical signs of illness were not observed. Of 18 cats with maternally derived antibody, 14 failed to develop an immune response after vaccination. Three of these 14 cats were exposed virulent virus and all developed typical signs of FPL. It was concluded that aerosol FPL vaccination is an effective and practicable method of immunizing large number of cats.