Association of plasma level of urokinase-type plasminogen activator,urokinase-type plasminogen activator receptor (uPAR),and plasminogen activator inhibitors type 1 with ovarian cancer

Objective To investigate the relationship between plasma level of urokinase-type plasminogen activator(uPA),urokinase-type plasminogen activator receptor(uPAR)and plasminogen activator inhibitor type 1(PAI-1)and ovarian cancer.Method The concentration of uPA,uPAR and PAI-1 in 52 patients with ovarian cancer and 30 healthy subjects were simultaneously determined by ELISA.Results There were significant differences for uPA and uPAR in different grades of the patients with ovarian cancer(P0.01).However,there was no significant difference for PAI-1 in ovarian cancer patients with different grades.There were significant differences in PAI-1,uPA,uPAR between the patients with ovarian cancer and healthy subjects(P0.01).Conclusion uPA,uPAR and PAI-1 may play important roles and be used as the parameters for progression and reimplantation of ovarian malignant cancer cells.