Influence of Benzoinum and Borneolum Syntheticum on Pharmacokinetics of Benzoic Acid and Cinnamic Acid in Rats

Objective: To study the pharmacokinetics of benzoic acid and cinnamic acid in rats plasma after oral administration of Benzoinum liquid or the mixing liquid of Benzoinum and Borneolum Syntheticum.Method: SD rats were divided into two groups randomly, giving Benzoinum liquid or the mixing liquid of Benzoinum and Borneolum Syntheticum respectively, collecting the plasma samples at different time. Then determining benzoic acid and cinnamic acid contents,and calculating the pharmacokinetic parameters. Result:The experiments showed the Tmaxwere( 41. 57 ± 1. 99),( 11. 42 ± 3. 78) min for benzoic acid,( 32. 86 ± 3. 13),( 11. 71 ±2.96) min for cinnamic acid. The maximum plasma concentration( Cmax) were( 34.93 ± 11.65),( 40. 35 ±22.72) mg·L- 1for benzoic acid,( 2. 96 ± 1. 10),( 3. 43 ± 1. 38) mg·L- 1for cinnamic acid. The AUC( 0 ~∞)were( 4 481. 42 ± 879. 21),( 3 942. 21 ± 977. 52) min·μg- 1·mL- 1for benzoic acid( 601. 16 ±45. 84),( 401. 33 ± 23. 35) min·μg- 1·mL- 1for cinnamic acid. Conclusion: In the compatibility of Benzoinum with Borneolum Syntheticum the Tmaxof benzoic acid and cinnamic acid were significantly reduced,suggesting that the compatibility of the two drugs can accelerate the absorption speed of benzoic and cinnamic acid in rats.