The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents

Environmental enrichment ("EE") is expected to alleviate the negative effects of stress on cognitive performance. However, there are complexities associated with interpreting interactions that obscure determining the benefit EE may play in mitigating the negative effects of stress. To clarify these complexities, we conducted a systematic review with meta-analysis on the main and interactive effects of EE and stress on learning and memory in rodents. We show that EE and stress interact 'synergetically' where EE provides a greater relative benefit to stressed individuals compared to those reared in conventional housing. Importantly, EE can fully-compensate for the negative effects of stress where stressed individuals with EE performed equally to enriched individuals without a stress manipulation. Additionally, we show the importance of other mediating factors, including the order of treatment exposure, duration and type of stress, type of EE, and type of cognitive assays used. This study not only quantifies the interactions between EE and stress, but also provides a clear example for how to conduct and interpret a meta-analysis of interactions.