医学
粒体自噬
心肌病
败血症
器官功能障碍
线粒体
收缩性
扩张型心肌病
线粒体生物发生
射血分数
心脏病学
内科学
心力衰竭
生物信息学
自噬
细胞生物学
生物
细胞凋亡
生物化学
作者
Oluwabukunmi Modupe Salami,Olive Habimana,Jin-Fu Peng,Guanghui Yi
标识
DOI:10.1007/s10557-022-07354-8
摘要
Sepsis is an increasingly worldwide problem; it is currently regarded as a complex life-threatening dysfunction of one or more organs as a result of dysregulated host immune response to infections. The heart is one of the most affected organs, as roughly 10% to 70% of sepsis cases are estimated to turn into sepsis-induced cardiomyopathy (SIC). SIC can be defined as a reversible myocardial dysfunction characterized by dilated ventricles, impaired contractility, and decreased ejection fraction. Mitochondria play a critical role in the normal functioning of cardiac tissues as the heart is highly dependent on its production of adenosine triphosphate (ATP), its damage during SIC includes morphology impairment, mitophagy, biogenesis disequilibrium, electron transport chain disturbance, molecular damage from the actions of pro-inflammatory cytokines and many other different impairments that are major contributing factors to the severity of SIC. Although mitochondria-targeted therapies usage is still inadequate in clinical settings, the preclinical study outcomes promise that the implementation of these therapies may effectively treat SIC. This review summarizes the different therapeutic strategies targeting mitochondria structure, quality, and quantity abnormalities for the treatment of SIC.
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