Structural characterization and protective effect of Lonicerae flos polysaccharide on cyclophosphamide-induced immunosuppression in mice

C NMR spectra, and scanning electron microscopy (SEM) analyses. Furthermore, LP obviously alleviated the injury of spleen and thymus; significantly promoted Interleukin-2 (IL-2), IL-6, tumor necrosis factor α (TNF-α), immunoglobulin (IgA, IgG and IgM) secretion; and improved the richness of gut microbiota and the contents of short-chain fatty acids (SCFAs) in immunosuppressive mice. Taken together, these results suggested that LP possessed strong protective effect on cyclophosphamide-induced immunosuppression in mice via modulating gut microbiota.