化学
三七
生物转化
立体化学
六边形
酮
皂甙
有机化学
生物化学
酶
医学
病理
替代医学
作者
Jia-Huan Shang,Yongxiang Li,Hongtao Zhu,Dong Wang,Yi-Jun Qiao,Chong‐Ren Yang,Yingjun Zhang
标识
DOI:10.1016/j.molstruc.2021.132096
摘要
• Notoginsenoids T1−T7, a new class of hexa-nortriterpenoids, were obtained. • Spectral, single-crystal X-ray, Mo 2 (AcO) 4 -induced CD and ECD analyzes were applied. • T1-T7 possess an unprecedented 9-en-5-ketone tricyclic hexa-nordammar skeleton. • A plausible biotransformed pathway for T1−T7 by degradation from PNS was proposed. • T1−T5 showed growth inhibitory effects on probiotic and pathogenic fungi of sanqi. Notoginsenoids T1−T7, a new class of hexa-nortriterpenoids including two dimers and five monomers, possessing an unprecedented 9-en-5-ketone tricyclic hexa-nordammar skeleton and a variable side chain at C-17, were obtained from biotransformation of PPD-type dammarane saponins by the soil harvested with Panax notoginseng (Araliaceae), a famous traditional Chinese medicinal herb. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction, Mo 2 (AcO) 4 -induced CD and ECD analyzes. A plausible biotransformed pathway for T1−T7 was proposed. Notoginsenoids T1−T5 showed growth inhibitory effects on the probiotic and pathogenic fungi of P. notoginseng .
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