化学
多米诺骨牌
组合化学
级联反应
基质(水族馆)
原子经济
范围(计算机科学)
催化作用
立体化学
有机化学
计算机科学
海洋学
地质学
程序设计语言
作者
Beeraiah Baire,Bhavna Yadav
标识
DOI:10.1002/adsc.202201030
摘要
Abstract Design and development of an acid‐catalyzed domino strategy for the rapid and selective generation of spiro‐polycyclic systems from propargylic alcohols is reported. Isolation of the intermediate olefins and the control experiments suggested and supported the proposed mechanism. The key features of this strategy are the selective access to spiro‐polycyclic systems, broad substrate scope (yields ranging between 50–95%), high atom economy, and operationally simple reaction procedure. We have extended this approach for the synthesis of spiro‐tetracyclic and spiro‐pentacyclic frameworks of dalesconols, and chamaecydin natural products respectively magnified image
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