Dual-Functional Nanobody Optical Probes for In Vivo Fluorescence Imaging and Photodynamic Therapy

imaging of mice bearing Hep3B tumors revealed clear visualization with a high signal-to-noise ratio. Furthermore, PEGylated probes significantly improved tumor retention, enhancing both imaging contrast and photodynamic therapy efficacy as compared to free chlorin e6. These dual-functional nanobody probes show great promise for the precise diagnosis and treatment of malignant tumors.