Co-occurring Melanoma in an Active Area of Vitiligo in Skin of Color

The association between vitiligo and melanoma is complex. While the incidence of vitiligo in patients with melanoma is higher, the risk for the reverse, ie, the development of melanoma in a patient with vitiligo, is thought to be decreased. This report presents a case of melanoma developing on a non-sun-exposed site in a patient with skin of color and untreated vitiligo. It emphasizes the need to think critically about vitiligo and melanoma pathogenesis. J Drugs Dermatol. 2025;24(2):205-206. doi:10.36849/JDD.8115.