Enhancing Lipase Immobilization via Physical Adsorption: Advancements in Stability, Reusability, and Industrial Applications for Sustainable Biotechnological Processes

Immobilization of lipases by physical adsorption improves their stability, recovery, and reusability in biotechnological processes. The present review provides an advanced bibliometric analysis and a comprehensive overview of research progress in this field. By searching Web of Science, 39,575 publications were analyzed, and 325 relevant articles were selected. Key journals, countries, institutions, and authors were identified. The most cited articles focus on biofuel production and industrial applications. The analysis revealed four research themes with a focus on the production of biofuel. The physical adsorption method is effective when the appropriate support is used. Despite a decrease in patent applications, industrial interest remains high. Future studies should focus on optimizing support materials and exploring new applications of this technique. The present review provides a detailed understanding of the immobilization of lipases by physical adsorption.