Antipsychotic polypharmacy carries lower risk of hospitalization than monotherapy

A nationwide cohort study of patients with schizophrenia has found that antipsychotic polypharmacy was associated with lower risk of hospitalization for physical health issues than antipsychotic monotherapy when high doses were used. The results call into question treatment guidelines that strongly recommend use of antipsychotic monotherapy over polypharmacy, the investigators stated. Study results were published online March 22, 2023, in the American Journal of Psychiatry.