芦丁
纳米载体
体内
化学
体外
细胞内
药物输送
细胞凋亡
药理学
核化学
生物化学
组合化学
生物物理学
有机化学
抗氧化剂
生物
生物技术
作者
Th. Abhishek Singh,Pritam Sadhukhan,Noyel Ghosh,Neelam Thakur,Anirudh Sharma,Neeraj Tejwan,Ashok Pabbathi,Joydeep Das,Parames C. Sil
标识
DOI:10.1016/j.mseb.2023.116623
摘要
Here, we constructed 4-carboxy phenylboronic acid (PBA) linked and amine functionalized MgO NPs (MgO-NH-PBA) loaded with rutin and investigated their in vitro and in vivo anticancer activities. The MgO-NH-PBA-Rutin nanohybrids exhibited ∼10 % drug loading capacity and a pH-responsive drug release pattern. MgO-NH-PBA-Rutin nanohybrid showed significant anticancer activity towards MDA-MB-231 cells via intracellular reactive oxygen species generation and apoptosis, and inhibited the migration of MDA-MB-231 cells. Further, in vivo studies also supported the superior anticancer potential of the nanohybrid in tumor-bearing mice. However, under both the conditions, MgO-NH-PBA-Rutin displayed the highest anticancer activity as compared with free rutin and MgO-NH-PBA. Molecular docking of rutin with BCl2 showed that rutin can bind to BCl2 with binding affinity −8.6 kcal/mol. The nanohybrid also did not exert any notable systemic toxicity towards other vital body organs. These findings suggested the use of MgO-NH-PBA as a potential nanocarrier for cancer treatment.
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