伤口愈合
炎症
癌症研究
活性氧
疤痕
细胞生物学
医学
免疫学
生物
病理
作者
Ying Zhang,Shenqiang Wang,Yinxian Yang,Shu Zhao,Jia You,J. Wang,Jingjing Cai,Dan Wang,Jie Wang,Wei Zhang,Jicheng Yu,Chunmao Han,Yuqi Zhang,Zhen Gu
标识
DOI:10.1038/s41467-023-39129-6
摘要
Abstract Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 ( En1 ) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models.
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