热重分析
纳米纤维
差示扫描量热法
乙烯醇
氧化苦参碱
材料科学
静电纺丝
纤维
傅里叶变换红外光谱
化学工程
壳聚糖
膜
核化学
高分子化学
化学
复合材料
纳米技术
聚合物
有机化学
色谱法
工程类
物理
热力学
生物化学
作者
Salahuddin Ahmed,Megan Keniry,Narcedalia Anaya-Barbosa,Victoria Padilla,Md Noushad Javed,Robert Gilkerson,Acharan S. Narula,Eman Ibrahim,Karen Lozano
标识
DOI:10.1002/mabi.202300098
摘要
This study focuses on the fabrication, characterization and anticancer properties of biocompatible and biodegradable composite nanofibers consisting of poly(vinyl alcohol) (PVA), oxymatrine (OM), and citric acid (CA) using a facile and high-yield centrifugal spinning process known as Forcespinning. The effects of varying concentrations of OM and CA on fiber diameter and molecular cross-linking are investigated. The morphological and thermo-physical properties, as well as water absorption of the developed nanofiber-based mats are characterized using microscopical analysis, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In vitro anticancer studies are conducted with HCT116 colorectal cancer cells. Results show a high yield of long fibers embedded with beads. Fiber average diameters range between 462 and 528 nm depending on OM concentration. The thermal analysis results show that the fibers are stable at room temperature. The anticancer study reveals that PVA nanofiber membrane with high concentrations of OM can suppress the proliferation of HCT116 colorectal cancer cells. The study provides a comprehensive investigation of OM embedded into nanosized PVA fibers and the prospective application of these membranes as a drug delivery system.
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