Myosin-Specific T Cells in Myocardial Diseases Revisited

HomeCirculationVol. 148, No. 1Myosin-Specific T Cells in Myocardial Diseases Revisited No AccessArticle CommentaryRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessArticle CommentaryRequest AccessFull TextMyosin-Specific T Cells in Myocardial Diseases Revisited Gustavo Ramos, Stefan Frantz and Ulrich Hofmann Gustavo RamosGustavo Ramos https://orcid.org/0000-0001-9582-2725 Department of Internal Medicine I/Comprehensive Heart Failure Center, University Hospital Würzburg, Germany Search for more papers by this author , Stefan FrantzStefan Frantz https://orcid.org/0000-0002-0301-6185 Department of Internal Medicine I/Comprehensive Heart Failure Center, University Hospital Würzburg, Germany Search for more papers by this author and Ulrich HofmannUlrich Hofmann Correspondence to: Ulrich Hofmann, MD, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg/Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0002-3681-2073 Department of Internal Medicine I/Comprehensive Heart Failure Center, University Hospital Würzburg, Germany Search for more papers by this author Originally published3 Jul 2023https://doi.org/10.1161/CIRCULATIONAHA.123.064453Circulation. 2023;148:4–6FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 6.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Ulrich Hofmann, MD, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg/Germany. Email hofmann_u2@ukw.deReferences1. Axelrod ML, Meijers WC, Screever EM, Qin J, Carroll MG, Sun X, Tannous E, Zhang Y, Sugiura A, Taylor BC, et al. T cells specific for alpha-myosin drive immunotherapy-related myocarditis.Nature. 2022; 611:818–826. doi: 10.1038/s41586-022-05432-3CrossrefMedlineGoogle Scholar2. Won T, Kalinoski HM, Wood MK, Hughes DM, Jaime CM, Delgado P, Talor MV, Lasrado N, Reddy J, Cihakova D. Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis.Cell Rep. 2022; 41:111611. doi: 10.1016/j.celrep.2022.111611CrossrefMedlineGoogle Scholar3. Gil-Cruz C, Perez-Shibayama C, De Martin A, Ronchi F, van der Borght K, Niederer R, Onder L, Lutge M, Novkovic M, Nindl V, et al. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy.Science. 2019; 366:881–886. doi: 10.1126/science.aav3487CrossrefMedlineGoogle Scholar4. Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Paula Longhi M, Vyas VS, Dyer C, Pontarini E, et al. Circulating c-Met-expressing memory T cells define cardiac autoimmunity.Circulation. 2022; 146:1930–1945. doi: 10.1161/CIRCULATIONAHA.121.055610LinkGoogle Scholar5. Rieckmann M, Delgobo M, Gaal C, Buchner L, Steinau P, Reshef D, Gil-Cruz C, Horst ENT, Kircher M, Reiter T, et al. Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses.J Clin Invest. 2019; 129:4922–4936. doi: 10.1172/JCI123859CrossrefMedlineGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails July 4, 2023Vol 148, Issue 1 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.064453PMID: 37399262 Originally publishedJuly 3, 2023 Keywordsautoimmune diseaseCTLA-4 antigenimmune checkpoint inhibitormyocarditisreceptors, antigen, T-cellPDF download Advertisement Subjects Inflammation