生发中心
RNA结合蛋白
细胞生物学
小RNA
翻译(生物学)
生物
信使核糖核酸
核糖核酸
MCL1
Rna处理
细胞凋亡
分子生物学
计算生物学
病毒学
B细胞
抗体
基因
遗传学
下调和上调
作者
Inés C. Osma-García,Maïlys Mouysset,Dunja Capitan-Sobrino,Yann Aubert,Martin Turner,Manuel D. Díaz-Muñoz
标识
DOI:10.1038/s41423-023-01063-4
摘要
Germinal centers (GCs) are essential for the establishment of long-lasting antibody responses. GC B cells rely on post-transcriptional RNA mechanisms to translate activation-associated transcriptional programs into functional changes in the cell proteome. However, the critical proteins driving these key mechanisms are still unknown. Here, we show that the RNA binding proteins TIA1 and TIAL1 are required for the generation of long-lasting GC responses. TIA1- and TIAL1-deficient GC B cells fail to undergo antigen-mediated positive selection, expansion and differentiation into B-cell clones producing high-affinity antibodies. Mechanistically, TIA1 and TIAL1 control the transcriptional identity of dark- and light-zone GC B cells and enable timely expression of the prosurvival molecule MCL1. Thus, we demonstrate here that TIA1 and TIAL1 are key players in the post-transcriptional program that selects high-affinity antigen-specific GC B cells.
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